Polycystic Ovary Syndrome (PCOS) affects millions of women globally, causing hormonal imbalances, fertility issues, and other complications. Among various supplements explored for managing PCOS, Coenzyme Q10 (CoQ10) has shown promising results in addressing symptoms such as insulin resistance, inflammation, and fertility issues. Here’s a look at how CoQ10 could benefit women with PCOS.

What is CoQ10?

Coenzyme Q10 is a naturally occurring antioxidant found in every cell of the body, helping to produce energy and protect cells from oxidative damage. While CoQ10 levels naturally decline with age, supplementation has been shown to offer health benefits, particularly for women with PCOS.

How CoQ10 supports women with PCOS

Emerging research shows that CoQ10 may play a significant role in addressing some key PCOS symptoms:

1. Improving fertility, egg quality and ovulatory function.
   One of the most well-known benefits of CoQ10 is its potential to improve fertility, especially for women with PCOS. CoQ10 helps protect eggs from oxidative damage, which is crucial for maintaining egg quality as women age. In women resistant to clomiphene citrate (a common fertility drug), CoQ10 supplementation improved ovulation rates, and the pregnancy rate in those taking CoQ10 was significantly higher compared to those taking the fertility drug alone.
   
   
2. Reducing insulin resistance and testosterone levels. 
   Insulin resistance is a hallmark of PCOS, often exacerbating other symptoms like weight gain, acne, and irregular periods. Clinical trials have shown that supplementing with CoQ10 can significantly reduce insulin levels and improve insulin sensitivity. Furthermore, CoQ10 has been shown to lower total testosterone levels, which can help with symptoms like hirsutism (excessive hair growth).
   
   
3. Decreasing inflammation and supporting cardiovascular health

   Chronic inflammation is a significant concern for women with PCOS, contributing to insulin resistance and increased risk of cardiovascular diseases. CoQ10’s antioxidant properties have been linked to reduced inflammatory markers, including C-reactive protein (CRP). In a study where women with PCOS took 200 mg of CoQ10 daily for eight weeks, there was a significant improvement in endothelial function, which is vital for heart health.

4. Boosting mood and mental wellbeing. 

Anxiety and depression are often associated with PCOS, affecting a woman’s mental health. In one clinical trial, women who took 100 mg of CoQ10 daily for 12 weeks reported improvements in both depression and anxiety symptoms.

Are there any side effects?

CoQ10 is generally considered safe and well tolerated. Some people may experience mild side effects, such as nausea or stomach upset, but these are rare. It's important to note that CoQ10 can lower blood pressure, so women already taking blood pressure-lowering medications should consult their doctor before starting supplementation. If you're on blood thinners, CoQ10 may reduce their effectiveness. Always consult your healthcare provider if you're unsure about any ingredients. 

How to take CoQ10 for PCOS

Doses of CoQ10 in studies range from 100 to 200 mg per day, and it is best taken with a meal containing healthy fats to enhance absorption. Foods high in good fats include vegetable oils (such as olive, canola, sunflower, soy, and corn), nuts, seeds, and fish. For those trying to improve fertility, maintaining consistency with supplementation is key as benefits build over time.

The bottom line

CoQ10 has shown great potential in supporting women with PCOS, particularly in improving fertility, lowering insulin resistance, reducing inflammation, and supporting overall metabolic health. While it’s no cure for PCOS, it’s a valuable addition to a holistic treatment plan, helping women take control of their health with confidence.

For more advice and evidence-based products that can help with PCOS, check out our curated collection of PCOS heroes.